Publications by authors named "J L Arne"

[Uveitis and tattoos].

Bull Acad Natl Med

June 2020

The complications of tattoos are multiple and known for many years. However, their success explains their exponential multiplication in all countries. This confirmed the development of two new complications: a localized or remote skin sarcoidosis reaction, as well as the development of clinical and histological uveitis.

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The esterification of alcohols with fatty acids is a universal mechanism to form inert storage forms of sterols, di- and triacylglycerols, and retinoids. In ocular tissues, formation of retinyl esters is an essential step in the enzymatic regeneration of the visual chromophore (11--retinal). Acyl-CoA wax alcohol acyltransferase 2 (AWAT2), also known as multifunctional -acyltransferase (MFAT), is an integral membrane enzyme with a broad substrate specificity that has been shown to preferentially esterify 11--retinol and thus contribute to formation of a readily available pool of retinoids in the eye.

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Article Synopsis
  • Cellular retinol-binding protein 1 (CRBP1) is crucial for the transport and metabolism of vitamin A, but its ligand uptake and release process is not fully understood.* -
  • The study presents the first structure of CRBP1 without a ligand and detailed structures when bound to retinoids, revealing significant changes in protein structure upon binding.* -
  • The conformational flexibility of apo-CRBP1 allows it to interact with ligands, while the more stable structure of the holoprotein ensures safe transport of vitamin A.*
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The recent development of telemedicine, i.e. the use of communication technologies to transfer medical information, raises special ethical and legal issues.

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Keratoconus is a slowly progressive, non-inflammatory disorder of the eye characterized by thinning and protrusion of the cornea. Typically diagnosed in the patient's adolescent years, keratoconus may lead to substantial distortion of vision primarily from irregular astigmatism and myopia, and secondarily from corneal scarring. The classic histopathologic features include breaks in Bowman's layer and thinning of the corneal stroma.

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