Powering well-being: Energy independence and mental health in a zone of ongoing disasters.

The archipelago of Puerto Rico has faced multiple natural disasters, including hurricanes and earthquakes, disrupting the mental health and daily lives of its residents. These disasters, combined with socio-political abandonment, have led to the deterioration of the electrical grid, exacerbating health disparities. This study aimed to explore the linkages between natural and structural disasters, mental health, and energy independence in Puerto Rico.

Spermidine Recovers the Autophagy Defects Underlying the Pathophysiology of Cell Trafficking Disorders.

Cell trafficking alterations are a growing group of disorders and one of the largest categories of Inherited Metabolic Diseases. They have complex and variable clinical presentation. Regarding neurological manifestations they can present a wide repertoire of symptoms ranging from neurodevelopmental to neurodegnerative disorders.

Bacteria as Precision Tools for Cancer Therapy.

The discovery at the end of the 20th century of genes that induce cell death revolutionised the biocontaintment of genetically manipulated bacteria for environmental or agricultural applications. These bacterial 'killer' genes were then assayed for their potential to target and control malignant cells in human cancers. The identification of the bacteriomes in different human organs and tissues, coupled with the observation that bacteria tend to accumulate near tumours, has opened new avenues for anti-cancer strategies.

Obsessive-compulsive disorder secondary to focal brain lesions: from lesions to networks.

Background: Obsessive-compulsive disorder (OCD) may develop following brain lesions, but lesion distribution and connectivity patterns are unknown.

Methods: OCD-associated lesions, identified from systematic literature search, were traced on common brain space and compared to control lesions (N=608). Topography was analyzed using brain atlases, and lesion location networks computed using normative functional connectivity (N=1000).