MicroRNAs signatures as potential molecular markers in mild cognitive impairment: a meta-analysis.

Mild cognitive impairment (MCI) is characterized by a decline in cognitive functioning without significant interference in daily activities. Its high heterogeneity and elevated conversion rate to dementia pose challenges for accurate diagnosis and monitoring, highlighting the urgent need to identify methodologies focused on the early detection and intervention of MCI. Due to their biological characteristics, microRNAs (miRNAs) are potential candidates as non-invasive molecular markers for the identification and assessment of MCI progression.

Morphological Analysis of the Retrotalar Pulley and Its Role in Flexor Hallucis Longus Impingement: Insights from a CT-Based Study.

The Flexor Hallucis Longus (FHL) is a muscle that can be subject to multiple conflicts. The most common conflict is due to inflammation of the tendon at the retrotalar pulley. The constraints exerted on the FHL are responsible for a pathology called functional Hallux Limitus.

Nematic versus Kekulé Phases in Twisted Bilayer Graphene under Hydrostatic Pressure.

We address the precise determination of the phase diagram of magic angle twisted bilayer graphene under hydrostatic pressure within a self-consistent Hartree-Fock method in real space, including all the remote bands of the system. We further present a novel algorithm that maps the full real-space density matrix to a 4×4 density matrix based on a SU(4) symmetry of sublattice and valley degrees of freedom. We find a quantum critical point between a nematic and a Kekulé phase, and show also that our microscopic approach displays a strong particle-hole asymmetry in the weak coupling regime.

Age-invariant genes: multi-tissue identification and characterization of murine reference genes.

Studies of the aging transcriptome focus on genes that change with age. But what can we learn from age-invariant genes-those that remain unchanged throughout the aging process? These genes also have a practical application: they can serve as reference genes in expression studies. Reference genes have mostly been identified and validated in young organisms, and no systematic investigation has been done across the lifespan.

The multi-omics signatures of telomere length in childhood.

Background: Telomere length is an important indicator of biological age and a complex multi-factor trait. To date, the telomere interactome for comprehending the high-dimensional biological aspects linked to telomere regulation during childhood remains unexplored. Here we describe the multi-omics signatures associated with childhood telomere length.