Truncated TrkB: The predominant TrkB Isoform in Nociceptors.

Truncated TrkB (TrkBT1), traditionally considered a dominant-negative regulator of full-length TrkB (TrkBTK+), remains poorly understood in peripheral sensory neurons, particularly nociceptors. Furthermore, sensory neuronal TrkB expression and function has been traditionally associated with non-nociceptive neurons, particularly Aδ low-threshold mechanoreceptors. This study challenges prevailing assumptions by demonstrating that TrkBT1 is the predominant TrkB isoform expressed in sensory neurons and plays a functional role in modulating neuronal activity.

A bacterial membrane-disrupting protein stimulates animal metamorphosis.

Unlabelled: Diverse marine animals undergo a metamorphic larval-to-juvenile transition in response to surface-bound bacteria. Although this host-microbe interaction is critical to establishing and maintaining marine animal populations, the functional activity of bacterial products and how they activate the host's metamorphosis program has not yet been defined for any animal. The marine bacterium stimulates the metamorphosis of a tubeworm called by producing a molecular syringe called metamorphosis-associated contractile structures (MACs).

Knowledge graph embeddings in the biomedical domain: are they useful? A look at link prediction, rule learning, and downstream polypharmacy tasks.

Summary: Knowledge graphs (KGs) are powerful tools for representing and organizing complex biomedical data. They empower researchers, physicians, and scientists by facilitating rapid access to biomedical information, enabling the discernment of patterns or insights, and fostering the formulation of decisions and the generation of novel knowledge. To automate these activities, several KG embedding algorithms have been proposed to learn from and complete KGs.

Impact of a Regional Pediatric Hematology/Oncology Fellowship Program in Guatemala.

Purpose: This study aimed to describe and assess the regional experience of a pediatric hematology/oncology fellowship program based in Guatemala.

Methods: The Unidad Nacional de Oncología Pediátrica (UNOP) in Guatemala City, Guatemala, is the only hospital in Central America dedicated exclusively to childhood and adolescent cancer. To address the regional need for specialists, a fellowship program in pediatric hematology/oncology was launched in 2003.

The Immunopeptidomics Ontology (ImPO).

The adaptive immune response plays a vital role in eliminating infected and aberrant cells from the body. This process hinges on the presentation of short peptides by major histocompatibility complex Class I molecules on the cell surface. Immunopeptidomics, the study of peptides displayed on cells, delves into the wide variety of these peptides.