Publications by authors named "J L Alexandre"
Background: Maintenance niraparib at an individualized starting dose (ISD) is established in platinum-sensitive recurrent ovarian cancer (PSROC). However, patients' perspectives on the burden of prolonged maintenance therapy have not been reported in prospective trials or routine practice.
Methods: In the real-life multicenter NiQoLe study, patients with PSROC received ISD maintenance niraparib.
Objectives: Limited information is available on the safety of a rechallenge with an immune checkpoint inhibitor (ICI) after occurrence of an immune-related adverse event (irAE). We aim to identify potential emergent safety signals.
Design: This is an update of our observational pharmacovigilance cohort study.
Objectives: Proton pump inhibitor (PPI) exposure can lead to hyponatraemia, which is a common cause of delirium. An association between PPI exposure and delirium without hyponatraemia has been suggested in the literature. We aimed to describe the association between reports of delirium and PPI exposure and to assess the association between PPI and delirium with and without hyponatraemia.
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- The ESICM Green Paper addresses the importance of environmental sustainability in intensive care units (ICUs) and proposes actionable strategies to reduce their ecological impact.
- A task force of experts assessed key areas for improvement and refined their strategies through a series of meetings and drafts.
- The paper emphasizes the need for energy efficiency, waste reduction, and education among healthcare professionals to ensure that high-quality patient care and sustainability go hand in hand.