Publications by authors named "J L Abad"
Metabolic dysfunction-associated steatohepatitis(MASH) is commonly seen in biopsy proven steatotic liver disease(SLD). Life-style intervention reaching a weight loss higher than 10% promotes MASH resolution, but this goal is only achieved by a small number of patients. Endoscopic sleeve gastroplasty(ESG) has recently emerged as a safe and effective option to promote weight loss in obese population.
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- Oxidoreductase enzymes, important in organic synthesis and pharmaceuticals, rely on NADH for reactions, creating a need for cost-effective NADH regeneration methods.
- This study introduces a new amino-functionalized viologen that, when combined with diaphorase, effectively generates bioactive NADH with high selectivity and efficiency.
- Testing revealed that this system significantly enhanced formate production compared to traditional methods, highlighting its potential for sustainable NADH regeneration at low energy requirements.
Strengthening Community Responses to Economic vulnerability (SeCuRE): a protocol of an HIV status-neutral pilot randomized clinical trial with transgender women of color in Detroit, Michigan.
Pilot Feasibility Stud
November 2024
Background: In the United States (US), transgender women of color experience cyclical, interlocking systems of structural and institutional oppression rooted in racism and transphobia, which fuel economic vulnerability. Together, cycles of intersecting racism, transphobia, and economic vulnerability create conditions that give rise to extreme HIV inequities among transgender women of color. Microeconomic interventions - designed to improve financial standing by increasing income generation and access to financial resources through entrepreneurship, cash transfers, and training - have the potential to address structural factors underlying HIV inequities.
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- The study aimed to assess the prognostic significance of circulating tumor DNA (ctDNA) in patients with localized pancreatic ductal adenocarcinoma (PDAC) undergoing neoadjuvant chemotherapy (NAC) using a specific testing method called digital droplet PCR (ddPCR).
- Researchers enrolled 84 patients and found that mutant KRAS ctDNA was present in a significant percentage of patients at various treatment stages, with clearance of ctDNA during NAC linked to better overall survival (OS).
- The presence of the KRAS G12V mutation after surgery was strongly associated with poorer survival outcomes, indicating its potential as a negative prognostic marker in this patient group.
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- Obstructive sleep apnea (OSA) significantly impacts cardiovascular event recurrence in patients with acute coronary syndrome (ACS), particularly in those without prior cardiovascular disease.
- The study identified two groups based on the severity of OSA and utilized proteomics to analyze plasma proteins, revealing 24 differentially expressed proteins associated with OSA severity.
- Bioinformatic analysis suggested that these proteins are involved in key molecular pathways related to immune function, cell signaling, and inflammation, linking OSA to adverse cardiovascular outcomes.