In-vitro Detection of Intramammary-like Macrocalcifications Using Susceptibility-weighted MR Imaging Techniques at 1.5T.

Purpose: The aim of our study was to investigate the technical accuracy of susceptibility-weighted imaging (SWI) and quantitative susceptibility mapping (QSM) created to detect intramammary-like calcifications depending on different TEs, volume, and type of calcification samples at 1.5T.

Methods: Jello-embedded particles of blackboard chalk and ostrich eggshell ranging in size from 4 to 25 mm were used to simulate intramammary calcifications after testing different base substances and calcifications for their suitability to be used in breast phantoms.

Lateral QRS amplitude is independently associated with outcome after cardiac resynchronization therapy: Advancing patient selection?

Background: Cardiac resynchronization therapy (CRT) is a cornerstone in the treatment of selected heart failure patients. However, a relevant proportion of patients do not show beneficial response. Identification of simple, additive, and outcome-relevant selection criteria may improve selection of patients.

Local therapy with combination TLR agonists stimulates systemic anti-tumor immunity and sensitizes tumors to immune checkpoint blockade.

Toll-like receptor (TLR) agonists are being developed as anti-cancer therapeutics due to their potent immunostimulatory properties. However, clinical trials testing TLR agonists as monotherapy have often failed to demonstrate significant improvement over standard of care. We hypothesized that the anti-cancer efficacy of TLR agonist immunotherapy could be improved by combinatorial approaches.

A review of the safety of oral immunotherapy in clinical trial and real-world studies.

Safety concerns are a barrier to oral immunotherapy (OIT). This review aims to describe OIT safety events and explore potential risk factors and mitigating factors. Published clinical and real-world OIT studies were reviewed for data on safety outcomes in OIT.