Effects of combined chronic nimodipine and acute metrifonate treatment on spatial and avoidance behavior.

The present experiment was designed to elucidate whether chronic dietary treatment with nimodipine (3 months, 1000 ppm) enhances water maze spatial navigation, passive avoidance behavior and locomotor activity, and whether such a treatment with nimodipine would interact with the therapeutic effect of acute metrifonate treatment. In young medial septum-lesioned rats, nimodipine had no effect by its own on cognitive or motor behavior, and did not enhance the water maze and passive avoidance behavior improving action of metrifonate (3 and 10 mg/kg. p.

Metrifonate improves spatial navigation and avoidance behavior in scopolamine-treated, medial septum-lesioned and aged rats.

We investigated the effects of acute p.o. pretraining treatment with an indirect acetylcholinesterase inhibitor, metrifonate, on water maze spatial navigation and passive avoidance behavior.

Effects of combined block of alpha 1-adrenoceptors and NMDA receptors on spatial and passive avoidance behavior in rats.

The present study was designed to investigate the interactions between alpha 1-adrenoceptors and NMDA receptors in modulating spatial navigation and passive avoidance behavior in rats. Pretraining treatment with prazosin, and alpha 1-adrenoceptor antagonist, at 2 mg/kg i.p.

Effects of thalamic and nucleus basalis infusions of nicotine on cortical EEG.

The present study was designed to investigate the hypothesis that nicotine may act via thalamic and basal forebrain nicotinic acetylcholine receptors to suppress neocortical high voltage spindling and slow waves in awake rats. Loca microinfusions of a nicotinic acetylcholine receptor agonist (nicotine 3, 10 and 30 micrograms) or antagonist (mecamylamine 10 micrograms) into the vicinity of the basal forebrain cholinergic projection neurones of the nucleus basalis had no effect on cortical EEG waves. However, nicotine (3, 10 and 30 micrograms) microinfusions into the thalamus decreased high voltage spindles and desynchronized non-spindling EEG waves in the cortex.

Effects of scopolamine infusions into the anterior and posterior cingulate on passive avoidance and water maze navigation.

We examined the role of anterior and posterior cingulate cortical muscarinic receptors in water maze spatial learning and passive avoidance. Pretraining and posttraining trial scopolamine (a mixed a muscarinic acetylcholine antagonist) infusions into the anterior cingulate cortex dose dependently (3 no effect; 10 and 30 micrograms impaired) impaired passive avoidance performance. Pretesting infusion into the anterior cingulate had no effect on passive avoidance.