A Revised Abaqus Procedure for Fracture Path Simulation Based on the Material Effort Criterion.

This paper presents the results of computer simulations of fracture in three laboratory tests: the three-point bending of a notched beam cut from sandstone, the pull-out test of a self-undercutting anchor fixed in sandstone, and the pull-out test of a bar embedded in concrete. Five material failure criteria were used: Rankine, Coulomb-Mohr, Drucker-Prager, Ottosen-Podgórski, and Hoek-Brown. These criteria were implemented in the Abaqus FEA system to work with the crack propagation modeling method-extended finite element method (X-FEM).

Geochemical insights of arsenic mobilization into the aquifers of Punjab, Pakistan.

It is well known that groundwater arsenic (As) contamination affects million(s) of people throughout the Indus flood plain, Pakistan. In this study, groundwater (n = 96) and drilled borehole samples (n = 87 sediments of 12 boreholes) were collected to investigate geochemical proxy-indicators for As release into groundwater across floodplains of the Indus Basin. The mean dissolved (μg/L) and sedimentary As concentrations (mg/kg) showed significant association in all studied areas viz.

Extracellular signals induce dynamic ER remodeling through αTAT1-dependent microtubule acetylation.

Dynamic changes in the endoplasmic reticulum (ER) morphology are central to maintaining cellular homeostasis. Microtubules (MT) facilitate the continuous remodeling of the ER network into sheets and tubules by coordinating with many ER-shaping protein complexes, although how this process is controlled by extracellular signals remains unknown. Here we report that TAK1, a kinase responsive to various growth factors and cytokines including TGF-β and TNF-α, triggers ER tubulation by activating αTAT1, an MT-acetylating enzyme that enhances ER-sliding.

Phosphoproteomic profiling identifies DNMT1 as a key substrate of beta IV spectrin-dependent ERK/MAPK signaling in suppressing angiogenesis.

βIV-spectrin is a membrane-associated cytoskeletal protein that maintains the structural stability of cell membranes and integral proteins such as ion channels and transporters. Its biological functions are best characterized in the brain and heart, although recently we discovered a fundamental new role in the vascular system. Using cellular and genetic mouse models, we reported that βIV-spectrin acts as a critical regulator of developmental and tumor-associated angiogenesis.