Publications by authors named "J Kroon"
Multicellular 3D models to study myocardial ischemia-reperfusion injury.
Front Cell Dev Biol
November 2024
Coronary heart disease is a major global health threat, with acute myocardial ischemia-reperfusion injury (IRI) being a major contributor to myocardial damage following an ischemic event. IRI occurs when blood flow to ischemic tissues is restored and exacerbates the cellular damage caused by ischemia/hypoxia. Although animal studies investigating IRI have provided valuable insights, their translation into clinical outcomes has been limited, and translation into medical practice remains cumbersome.
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- The study focuses on Tc-fucoidan, a compound derived from brown algae, which targets P-selectin for early identification of thrombosis.
- In the safety assessment involving ten healthy volunteers, Tc-fucoidan was well tolerated with no adverse effects and demonstrated reliable uptake in human thrombi in gamma counting experiments.
- Although the results showed potential for imaging thrombi in certain cases, the overall findings do not support further clinical use of Tc-fucoidan for diagnosing deep vein thrombosis (DVT), suggesting exploration of alternative P-selectin tracers instead.
Article Synopsis
- Stimulation of mammalian cells with inflammatory inducers, like lipopolysaccharide (LPS), alters cellular metabolic pathways, particularly affecting enzymes in the tricarboxylic acid (TCA) cycle, which is crucial for releasing pro-inflammatory cytokines.
- The study found that patients with certain genetic variants affecting fatty acid oxidation exhibited inadequate inflammatory responses to LPS due to issues with TLR4 expression and signaling.
- The findings suggest that genes involved in fatty acid metabolism are essential not just for energy production but also for proper immune responses, shedding light on disease mechanisms in conditions like long-chain fatty acid oxidation disorders (lcFAODs).
Aim: To determine the impact of the COVID-19 pandemic on depression, anxiety and stress of dental students by way of a systematic review.
Materials And Methods: This review was conducted following the Cochrane Handbook for Systematic Reviews. An electronic search was conducted for the period January 2020 to February 2023.
Objective: Endogenous glucocorticoid levels display a strong circadian rhythm, which is often not considered when synthetic glucocorticoids are prescribed as anti-inflammatory drugs. In this study we evaluated the effect timing of glucocorticoid administration, i.e.
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