Publications by authors named "J Krejsek"
Objectives: Given the high worldwide prevalence of vitamin D deficiency and its role in numerous diseases affecting mortality and morbidity, this study seeks to determine the prevalence of low 25-hydroxyvitamin D levels in the Czech Republic, where population-level data are currently lacking.
Study Design: This retrospective study utilized a large dataset to analyze 25-hydroxyvitamin D levels over an extended period.
Methods: We analyzed data from 119,925 individuals aged 0-100 years categorizing them as sufficient (75-250 nmol/L), insufficient (50-75 nmol/L), or deficient (<50 nmol/L).
Introduction: A critical step preceding the potential biomedical application of nanoparticles is the evaluation of their immunomodulatory effects. Such nanoparticles are expected to enter the bloodstream where they can be recognized and processed by circulating monocytes. Despite the required biocompatibility, this interaction can affect intracellular homeostasis and modulate physiological functions, particularly inflammation.
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- The study aimed to analyze the sensitization to latex and food allergens in atopic dermatitis patients using the ALEX2 Allergy Xplorer test, comparing the results with personal histories of allergies.
- The study included 100 patients, examining specific IgE responses to latex and collecting detailed allergy histories.
- The findings revealed 17% sensitization to latex, primarily linked to specific protein components, with some patients showing allergic reactions to latex or related fruit syndromes, underscoring the connections between molecular components and clinical reactions.
Our aim is to determine the number of leukocytes, T lymphocytes and B lymphocytes and the expression of activation markers CD200 and CD23 on B lymphocytes in atopic dermatitis (AD) patients (treated and not treated with dupilumab) during the pollen season. We examined 29 patients not treated with dupilumab, 24 patients treated with dupilumab and 40 healthy subjects as a control group. The count of T and B lymphocytes and their subsets were assessed by flow cytometry.
View Article and Find Full Text PDFBackground: Natural killer cells (NK) and innate lymphoid cells with their subsets (ILC) are part of the innate immune system.
Objective: The aim is to evaluate how NK cells and ILC cells interact in atopic dermatitis (AD) patients (with and without dupilumab therapy) compared to control group.
Materials And Methods: Complete dermatological examination was performed in all patients included in the study (19 AD patients with dupilumab, 17 AD patients without dupilumab).