Publications by authors named "J Krahn"
Coronaviruses evade detection by the host immune system with the help of the endoribonuclease Nsp15, which regulates levels of viral double stranded RNA by cleaving 3' of uridine (U). While prior structural data shows that to cleave double stranded RNA, Nsp15's target U must be flipped out of the helix, it is not yet understood whether Nsp15 initiates flipping or captures spontaneously flipped bases. We address this gap by designing fluorinated double stranded RNA substrates that allow us to directly relate a U's sequence context to both its tendency to spontaneously flip and its susceptibility to cleavage by Nsp15.
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- Spatial judgement bias tests (JBTs) assess an animal's expectation of reward based on their approach to ambiguous locations between rewarded and unrewarded bowls, reflecting their level of 'optimism' and potential welfare.
- A study involving 16 companion dogs tested whether a learning treatment (different discrimination trials) would impact their 'optimism' in a subsequent JBT.
- The results indicated that the additional discrimination trials did not change the dogs' approach latencies to ambiguous locations, suggesting that their 'optimism' remained unaffected by the learning treatment.
Dairy cows compete for feed and water access on commercial farms. In this study we used EloSteepness to assess the summed Elo winning probabilities (i.e.
View Article and Find Full Text PDFBackground: The incidence of sexually transmitted infections (STI) continues to increase worldwide. Patient incentives are one proposed intervention to increase STI testing and treatment.
Methods: We conducted a retrospective cohort study comparing incentivized versus routine care for STI outreach test and treat services between October 2018 and June 2019.
Background: When the Measles Protection Act as part of the Infection Protection Act came into force 2020, various types of facilities were obliged to report. The public health department of the city of Darmstadt and the district of Darmstadt Dieburg aimed to find out to what extent these facilities have complied with the reporting obligation and whether any conclusions could be derived from the data on the vaccination status of the respective group of people.
Method: Reports from the facilities and the feedback from those affected (or their legal guardians) were reviewed and evaluated descriptively.