Chemotherapy as initial management of patients with operable colorectal cancer.

The evidence in support of the concepts of PrCh and of anticoagulation in the management of primary CRCa are briefly presented. The first study incorporating both these novel approaches to the treatment of CRCa with a minimum follow-up of 5 years is herein presented. Whereas no discernible differences on survival were documented on a long-term basis, when patient who ultimately recurred in each group were compared, a substantial and statistically significant prolongation of the free-of-disease interval from surgery to recurrence and of survival from recurrence to death are revealed.

Pre- and postoperative chemoendocrine treatment with or without postoperative radiotherapy for locally advanced breast cancer.

From July, 1978 to September, 1981, 184 patients with localy advanced breast cancer (T3; T4a-b; any N; M0) regardless of their hormonal receptor status, entered a trial to evaluate the contribution of radiotherapy when added to an intensive preoperative chemoendocrine regimen. Seventy-eight patients were ultimately disqualified. All patients underwent sequentially: (1) two cycles of chemotherapy: Day 1--Oncovin 1.