Publications by authors named "J Kozeluhova"
Article Synopsis
- The study aimed to assess the effectiveness and safety of adalimumab biosimilars FKB327 and GP2017 in treating patients with inflammatory bowel disease (IBD), focusing on Crohn's disease (CD) and ulcerative colitis (UC).
- Of the 50 patients treated, 73.5% with CD achieved remission after 12 weeks, while only 18.8% of UC patients reached remission; overall improvements in disease activity and lab results were noted.
- Seven adverse events were reported, leading to three cases where therapy was discontinued, indicating that while effective, the treatment has potential side effects.
Background And Aims: Ulcerative colitis (UC) is a chronic inflammatory disease. Fecal microbial transplantation (FMT) is a promising alternative treatment.
Methods: This multicenter, open-label, noninferiority trial randomized patients with active left-sided UC (Mayo score 4-10) equally to FMT or 5-aminosalicylic acid (5-ASA) enemas.
Background: Motility disorders of upper gastrointestinal tract are common in critical illness and associated with significant clinical consequences. However, detailed quantitative and qualitative analyses of esophageal motor functions are lacking. Therefore, we aimed to characterize the key features of esophageal motility functions using high-resolution impedance manometry (HRIM) and to evaluate an objective link between esophageal motor patterns, gastric emptying, and gastroesophageal reflux.
View Article and Find Full Text PDFPortal vein thrombosis (PVT) is a partial or complete thrombotic occlusion of the portal vein and is rare in noncirrhotic patients. 78 adult patients with noncirrhotic acute PVT without known malignity were evaluated. Patients with initial CRP level 61-149 mg/l were excluded.
View Article and Find Full Text PDFBackground: Evidence of the impact of in utero exposure to anti-tumor necrosis factor (TNF)-alpha on long-term childhood development is limited. The aim was to assess the impact of in utero exposure to anti-TNF-alpha due to mothers' inflammatory bowel disease (IBD) on long-term postnatal development of exposed children.
Methods: We included consecutive children (≥12 months of age) born to mothers with IBD (2007-2016) treated with anti-TNF-alpha during pregnancy in 3 centers in the Czech Republic.