Association of Gene Polymorphism and Serum Level of α Klotho Protein with Different Tumor Grades, Overall Survival and Cytokine Profile in Glioma Patients.

Gliomas are the most common and lethal forms of malignant brain tumors. We attempted to identify the role of the aging-suppressor gene and Klotho protein in the immunopathogenesis of gliomas. We examined genetic variants by PCR-RFLP and measured serum Klotho levels using the ELISA method.

The Evaluation of Glyceryl C3-Azolyl-Thiogalactosides as Galectin-1 and Galectin-3 Ligands.

Galectins are a family of galactoside-binding proteins involved in various pathophysiological processes, which makes them attractive targets for drug discovery. The derivatization of d-galactose at C3 and C1 positions has been shown to increase the affinity of synthetic galectin antagonists. In this study, two small libraries of d-galactose derivatives have been designed and synthesized.

How sociodemographic factors relate to trust in artificial intelligence among students in Poland and the United Kingdom.

The article aims to determine the sociodemographic factors associated with the level of trust in artificial intelligence (AI) based on cross-sectional research conducted in late 2023 and early 2024 on a sample of 2098 students in Poland (1088) and the United Kingdom (1010). In the times of AI progressively penetrating people's everyday life, it is important to identify the sociodemographic predictors of trust in this increasingly dynamically developing technology. The theoretical framework for the article is the extended Unified Theory of Acceptance and Use of Technology (UTAUT), which highlights the significance of sociodemographic variables as predictors of trust in AI.

Fast onset of thrombolytic effect of efficiently inhalable spray-dried rivaroxaban powder formulations.

Pulmonary embolism is a critical medical condition and can lead to cardiovascular arrest or death if left untreated. Pulmonary delivery of an anti-coagulant therapeutic could provide a locally limited and efficient therapy, moreover combined with a potentially fast onset of the therapeutic effect that is demanded in emergency situations. Rivaroxaban (riva) was formulated as an inhalable dry powder that can be administered directly to the lungs in order to reach high local drug doses.

Identification of the Cohesive Parameters for Modelling of Bonded Joints between Flat Composite Adherends with Thick Layer of Adhesive.

The failure of bonded composite materials is accompanied by specific failure modes. These are specifically Mode I, Mode II, Mode III, and their combination (so-called mixed mode). These modes depend on the direction and type of loading.