Publications by authors named "J Kos"
Metabotropic glutamate receptors are a family of eight class C G protein-coupled receptors regulating higher order brain functions including cognition and motion. Metabotropic glutamate receptors have thus been heavily investigated as potential drug targets for treating neurological disorders. Drug discovery efforts directed toward metabotropic glutamate receptor subtype 5 (mGlu) have been particularly fruitful, with a wealth of drug candidates and pharmacological tools identified.
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- Researchers synthesized eighteen new compounds called 2-trifluoromethylcinnamanilides and studied their effects against Mycobacterium smegmatis and Plasmodium falciparum, with promising results for certain substituted variants.
- The most effective compounds against M. smegmatis were those with specific trifluoromethyl substitutions, while several anilides also showed strong activity against P. falciparum, with some comparable to chloroquine.
- Initial cytotoxicity tests revealed that some compounds had toxic effects, but others did not, and further studies indicated that two compounds were stable and did not interfere with liver metabolism, enhancing their potential as dual-action antimicrobials.
Hepatocyte growth factor (HGF) is a protective factor against acute renal injury and chronic renal fibrosis. A positive correlation between HGF and blood pressure (BP) has been established. This study aimed to determine the association between serum HGF concentration and albuminuria in subjects with optimal blood pressure (OBP) and untreated arterial hypertension (UAH), as well as its association with BP levels, serum glucose levels, and inflammatory markers.
View Article and Find Full Text PDFOne of the definitions of chemical biology is that it is a scientific discipline spanning the fields of chemistry, biology, and physics; it primarily involves the application of chemical techniques, tools, analyses, and often compounds (also known as chemical probes), which are produced through synthetic chemistry, in order to study and manipulate biological systems [...
View Article and Find Full Text PDFCarotid-femoral pulse wave velocity (cfPWV), acknowledged as a reliable proxy of arterial stiffness, is an independent predictor of cardiovascular (CV) events. Carotid-femoral PWV is considered the gold standard for the estimation of arterial stiffness. cfPWV is a demanding, time consuming and expensive method, and an estimated PWV (ePWV) has been suggested as an alternative method when cfPWV is not available.
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