Stem cell mTOR signaling directs region-specific cell fate decisions during intestinal nutrient adaptation.

The adult intestine is a regionalized organ, whose size and cellular composition are adjusted in response to nutrient status. This involves dynamic regulation of intestinal stem cell (ISC) proliferation and differentiation. How nutrient signaling controls cell fate decisions to drive regional changes in cell-type composition remains unclear.

National Hockey League Fights per Game and Viewership Trends: 2000-2020.

Background: Though once considered an integral part of professional hockey, fighting carries significant health risks to players. Fighting has remained legal in the National Hockey League (NHL) due to its purported economic and entertainment value. However, fights per game have diminished over the past 20 years, challenging the necessity of fighting to promote fan attendance.

Fighting in professional ice hockey: it's time for a change.

Ice hockey has long been defined by a level of violence not seen in other sports. The rough-and-tough vigilante nature of the game was often employed as a method of enticing fans. Play in the National Hockey League (NHL) evolved throughout the 20 century as the rules governing it did.

Age-related changes in polycomb gene regulation disrupt lineage fidelity in intestinal stem cells.

Tissue homeostasis requires long-term lineage fidelity of somatic stem cells. Whether and how age-related changes in somatic stem cells impact the faithful execution of lineage decisions remains largely unknown. Here, we address this question using genome-wide chromatin accessibility and transcriptome analysis as well as single-cell RNA-seq to explore stem-cell-intrinsic changes in the aging intestine.

Publisher Correction: The mutational impact of culturing human pluripotent and adult stem cells.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.