Publications by authors named "J Korta-Murua"
Exhaled Volatile Organic Compounds for Asthma Control Classification in Children with Moderate to Severe Asthma: Results from the SysPharmPediA Study.
Am J Respir Crit Care Med
November 2024
Article Synopsis
- Early identification of poorly controlled asthma in children is crucial for improving treatment methods, and analyzing exhaled volatile organic compounds (VOCs) shows promise for this task.
- A study evaluated the effectiveness of gas chromatography-mass spectrometry to distinguish between controlled and uncontrolled pediatric asthma, using data from multiple research phases.
- Key findings revealed that specific VOCs, such as acetophenone and ethylbenzene, could differentiate asthma control levels, achieving strong accuracy in predicting outcomes based on the collected data from 196 children.
The Spanish Guideline on the Management of Asthma, better known by its acronym in Spanish GEMA, has been available for more than 20 years. Twenty-one scientific societies or related groups both from Spain and internationally have participated in the preparation and development of the updated edition of GEMA, which in fact has been currently positioned as the reference guide on asthma in the Spanish language worldwide. Its objective is to prevent and improve the clinical situation of people with asthma by increasing the knowledge of healthcare professionals involved in their care.
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- Recognizing the different phenotypes of pediatric asthma allows for tailored treatment options, focusing on specific underlying mechanisms and biomarkers.
- Biologic therapies are increasingly significant for treating severe asthma in children, particularly targeting the most common T2 phenotype.
- This review discusses the action, effectiveness, and potential biomarkers of several biologic drugs—omalizumab, mepolizumab, benralizumab, dupilumab, and 1ezepelumab—highlighting varying prescription guidelines between the FDA and EMA.
We studied 295 children (tuberculosis disease, n = 159; latent tuberculosis infection, n = 136) with positive QuantiFERON-TB Gold-Plus assay results. No significant differences between first and second antigen tube interferon-gamma responses were detected, irrespective of patient and disease characteristics at diagnosis. Of patients with a repeat assay after treatment completion (n = 65), only 16.
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- The study investigates how genetics influence the upper airway microbiome's role in asthma exacerbations, even with inhaled corticosteroid treatments.
- Researchers analyzed samples from 257 European asthma patients, focusing on the link between genetic variants and microbiome traits related to asthma exacerbations and responses to treatment.
- Results indicated that specific genes associated with asthma-related microbiome traits are influenced by various factors, like comorbid conditions and specific transcription factors, with replication of findings in diverse populations.