Publications by authors named "J Kordower"
Introduction: Primary synucleinopathies, such as Parkinson's disease (PD), Dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), are neurodegenerative disorders with some shared clinical and pathological features. Aggregates of alpha-synuclein (αsyn) phosphorylated at serine 129 (PSER129) are the hallmark of synucleinopathies, which for PD/DLB are found predominantly in neurons (Neuronal cytoplasmic inclusions "NCIs"), but for MSA, aggregates are primarily found in oligodendroglia (Glial cytoplasmic inclusions "GCIs"). It remains unclear if the distinct pathological presentation of PD/DLB and MSA are manifestations of distinct or shared pathological processes.
View Article and Find Full Text PDFIntroduction: The understanding of the pathological events in Alzheimer's disease (AD) has advanced dramatically, but the successful translation from rodent models into efficient human therapies is still problematic.
Methods: To examine how tau pathology can develop in the primate brain, we injected 12 macaques with a dual tau mutation (P301L/S320F) into the entorhinal cortex (ERC). An investigation was performed using high-resolution microscopy, magnetic resonance imaging (MRI), positron emission tomography (PET), and fluid biomarkers to determine the temporal progression of the pathology 3 and 6 months after the injection.
Article Synopsis
- - Multiple system atrophy (MSA) is a rare, rapidly progressing neurodegenerative disease characterized by the presence of alpha-synuclein inclusions and results in severe brain damage, including demyelination and inflammation.
- - Researchers used a modified AAV to study the role of CD8+ T cells in MSA by creating a mouse model, revealing significant infiltration of these cells into the striatum after inducing MSA-related pathology.
- - Findings showed that while CD8+ T cells do not drive MSA progression, they play a role in modulating neuroinflammation and demyelination, which alters disease responses.