Publications by authors named "J Korbecki"

One of the aspects of tumor metabolism that distinguish it from healthy tissue is the phosphorylation of choline by choline kinases, which initiates the synthesis of phosphatidylcholine. Presently, there is a lack of comprehensive reviews discussing the current understanding of the role of choline kinase in cancer processes, as well as studies on the anti-tumor properties of choline kinase inhibitors. To address these gaps, this review delves into the enzymatic and non-enzymatic properties of CHKα and CHKβ and explores their precise involvement in cancer processes, particularly cancer cell proliferation.

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Background/objectives: Acute myeloid leukemia (AML) is a type of leukemia with a very poor prognosis. Consequently, this neoplasm is extensively researched to discover new therapeutic strategies. One area of investigation is the study of intracellular communication and the impact of the bone marrow microenvironment on AML cells, with chemokines being a key focus.

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Phospholipids are crucial structural components of cells. Phosphatidylcholine and phosphatidylethanolamine (both synthesized via the Kennedy pathway) and phosphatidylserine undergo interconversion. The dysregulation of this process is implicated in various diseases.

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Article Synopsis
  • Extensive research has focused on the CXCL12-CXCR4 axis in acute myeloid leukemia (AML), leading to the development of new anti-leukemia drugs targeting this pathway.
  • The review highlights the axis's role in cancer progression, covering its influence on growth, resistance to treatment, and interactions with other cell types like MSCs and T cells.
  • It also discusses the clinical implications of the CXCL12-CXCR4 axis, including its connections to prognosis and specific mutations, as well as examining various drugs that target this axis and their therapeutic potential in AML.
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This review delves into the enzymatic processes governing the initial stages of glycerophospholipid (phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine) and triacylglycerol synthesis. The key enzymes under scrutiny include GPAT and AGPAT. Additionally, as most AGPATs exhibit LPLAT activity, enzymes participating in the Lands cycle with similar functions are also covered.

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