Cephalosporins for Outpatient Pyelonephritis in the Emergency Department: COPY-ED Study.

Study Objective: The primary objective of our study was to compare the effectiveness of oral cephalosporins versus fluroquinolones and trimethoprim/sulfamethoxazole (TMP-SMX) for the treatment of pyelonephritis in patients discharged home from the emergency department (ED).

Methods: This was a multicenter, retrospective, observational cohort study of 11 geographically diverse US EDs. Patients aged ≥18 years diagnosed with pyelonephritis and discharged home from the ED between January 1, 2021 and October 31, 2023 were included.

On the Billefjorden fault zone in Garmdalen, central Spitsbergen: implications for the mapping of major fault zones during geological fieldwork and for the tectonic history of Svalbard.

Background: The present contribution reexamines the geometry of a segment of a presumably long-lived fault in Svalbard, the Balliolbreen Fault segment of the Billefjorden Fault Zone, along which presumably two basement terranes of Svalbard accreted in the early-mid Paleozoic after thousands of kilometers strike-slip displacement.

Methods: We performed structural fieldwork to Billefjorden in central Spitsbergen and interpreted satellite images.

Results: Field observations demonstrate that the Balliolbreen Fault formed as a top-west thrust fault in the early Cenozoic and that weak sedimentary units such as shales of the Lower Devonian Wood Bay Formation and coals of the uppermost Devonian-Mississippian Billefjorden Group partitioned deformation, resulting in significant contrast in deformation intensity between stratigraphic units.

Efficiency and safety of high-dose undiluted intravenous push levetiracetam loading doses compared to intravenous infusion in seizing patients: A retrospective cohort study.

Objective: Intravenous (IV) push (IVP) is an alternative administration method for levetiracetam, but evidence evaluating it compared to IV piggyback (IVPB) for loading doses in acutely seizing patients is limited, particularly in patients with status epilepticus (SE). This study aimed to compare the efficiency and safety of IVP versus IVPB levetiracetam loading doses.

Methods: This was a single-center sequential retrospective study conducted in adult (≥18 years) patients who received an IV levetiracetam loading dose (>2000 mg or ≥20 mg/kg) for acute or suspected seizure.

EDucated: The emergency medicine pharmacotherapy literature of 2023.

The purpose of this article is to summarize pharmacotherapy related emergency medicine (EM) literature indexed in 2023. Articles were selected utilizing a modified Delphi approach. The table of contents from pre-determined journals were reviewed and independently evaluated via the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system by paired authors.

Implications of Timanian thrust systems in the Barents Sea and Svalbard on using paleontological constraints for plate tectonics reconstructions.

Background: The Svalbard Archipelago is commonly believed to have been located at comparable latitude and, possibly, to have been attached to Laurentia in the early Paleozoic (500-420 Ma) based on trilobite assemblage similarities. Trilobite assemblage differences and lack of mixing between Laurentia-Svalbard and Baltica were further used to propose that these continents were separated by the Iapetus Ocean at that time. However, recent structural correlation of Timanian (650-550 Ma) thrust systems throughout the Barents Sea show that Svalbard was already attached to Baltica in the latest Neoproterozoic and remained so during the Phanerozoic.