Hepatic infarction complicating a transjugular intrahepatic portosystemic shunt.

Transjugular intrahepatic portocaval shunt (TIPS) is being used with increasing frequency to treat variceal bleeding and portal hypertension. Like any other invasive vascular procedure, it has the potential for serious complications. We report a case of a woman who underwent a TIPS procedure for variceal bleeding due to hepatitis C and sustained a hepatic infarction as a complication of the procedure.

Discrepancy between biochemical and virological responses to interferon-alpha in chronic hepatitis C.

Serial serum samples and pretreatment and post-treatment liver tissue from patients with chronic hepatitis C virus (HCV) infection were tested for HCV RNA by reverse-transcription polymerase chain reaction and branched DNA signal amplification assays. At the end of treatment with interferon-alpha (IFN alpha), 4 of 5 patients showing no biochemical response (in alanine aminotransferase activity), 4 of 5 with transient responses, and 1 of 5 showing complete and sustained responses had HCV RNA detectable in serum. The corresponding numbers for liver tissue were 5, 5, and 0 (of 4).

Significance of serum hepatitis C virus RNA levels in chronic hepatitis C.

Hepatitis C virus (HCV) is the main cause of parenteral non-A, non-B hepatitis and serum can be tested for the virus itself by reverse-transcription polymerase chain amplification. What of the level of this viraemia? To find out if quantitative study of HCV RNA might be useful clinically we took advantage of participation in trials of interferon-alpha in patients with chronic HCV infection and applied a new assay, branched DNA (bDNA) signal amplification. Paired serum and liver biopsy specimens from 47 patients with confirmed chronic HCV infection and evidence of HCV RNA in their serum were studied.