Purification and characterization of lectin from Phyllanthus reticulatus (PRL) plant fruit inducing cytotoxic effect on T47D and SKBR3 breast cancer cell lines.

Lectins are a heterogeneous group of carbohydrate-binding proteins that vary in size, structure, molecular organization, and binding patterns. They evoke diverse biological responses by specifically binding to cell surface glycans and function as recognition molecules. In this study, a lectin from the fruit of Phyllanthus reticulatus was purified using mucin-affinity chromatography.

Comparable Limb Salvage Outcomes on Pop Distal Bypass when Using Plantar Artery as a Distal Target.

Objective: The primary objective is to describe limb salvage and patency rates of infra-genicular bypasses using plantar artery as a distal target. The secondary objective is to compare outcomes between bypasses to the plantar artery and those to other tibial arteries.

Methods: Retrospective cohort study of all consecutive patients who underwent infra-genicular bypasses using autologous venous conduit from July 2012 to June 2018.

Lateral Calcaneal Artery Perforator/Propeller Flap in the Reconstruction of Posterior Heel Soft Tissue Defects.

 Posterior heel soft tissue defects with/without tendoachilles injury are difficult to reconstruct because of bony prominence, limited expendable local soft tissues, and significant donor site morbidity. In this study, we evaluate the lateral calcaneal artery (LCA) perforator/propeller flap for posterior heel soft tissue defect reconstruction.  A preliminary cadaveric study was done on 22 specimens to study the course of the LCA and its perforators.

Practical implementation of automated insulin delivery systems in 2025: A French position statement update.

The advent of automated insulin delivery (AID) systems in 2020 marked a disruptive event in managing type 1 diabetes, benefiting children and adults alike. By 2024, advances in real-world data and research motivated an update to the French consensus on AID systems to expand accessibility, refine guidelines, and optimize patient follow-up. AID systems have consistently improved glycemic control by reducing HbA1c, increasing time-in-range (TIR), and minimizing hypoglycemia, with significant benefits even for specific populations such as individuals with poor glycemic control, brittle diabetes, children, very young children, pregnant women, those with insulin resistance or gastroparesis, or after bariatric surgery.