Publications by authors named "J Klopper"
Isthmic thyroid nodules are more likely to be malignant and isthmic differentiated thyroid cancer demonstrates less favorable behavior compared with lobar locations. The goal of this study was to assess molecular differences of thyroid nodules and carcinomas from the isthmus relative to the lobes. The Afirma thyroid nodule database ( = 177,227) was assessed for cytologic and molecular differences between isthmus and lobar nodules in this observational cohort study.
View Article and Find Full Text PDFContext: Telomerase reverse transcriptase (TERT) promoter-mutated thyroid cancers are associated with a decreased rate of disease-free and disease-specific survival. High-quality analytical validation of a diagnostic test promotes confidence in the results that inform clinical decision-making.
Objective: This work aimed to demonstrate the analytical validation of the Afirma TERT promoter mutation assay.
Objective: The objective of this study was to analyze the risk of malignancy and the histopathology of telomerase reverse transcriptase promoter mutated cytologically indeterminate thyroid nodules (ITN).
Methods: A PUBMED search of molecularly tested ITN was conducted and data on mutated ITN with histopathology correlation were extracted.
Results: Twenty-six manuscripts (published between 2014 and 2022) reported on 77 mutated ITN.
Context: Serum thyroglobulin (Tg) is a biochemical marker for detecting persistent or recurrent differentiated thyroid carcinoma (DTC) post-thyroidectomy. Tg can indicate DTC before structural disease (SD) is visible with imaging procedures.
Objective: This work aimed to evaluate the clinical performance of the Elecsys Tg II assay at a Tg cutoff of 0.