Publications by authors named "J Kladny"

There is emerging interest in the relationship between several serum micronutrients and the prognosis of patients with breast cancer. The relationship between serum zinc and copper levels and breast cancer prognosis is unclear. In our study, we included 583 patients with breast cancer diagnosed between 2008 and 2015 in the region of Szczecin, Poland.

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There is a need for sensitive and specific biomarkers for the early detection of colorectal cancer. In this retrospective study, we assessed whether a high blood copper level was associated with the presence of colorectal cancer. The blood copper level was measured among 187 colorectal cancer patients and 187 matched controls.

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Article Synopsis
  • * Results showed that low blood arsenic levels (0.27-0.67 µg/L) were linked to a higher frequency of CRC, with odds ratios (OR) indicating a significant association (e.g., OR: 3.69).
  • * Furthermore, certain gene variants enhanced this correlation, with very high odds ratios for specific polymorphisms, suggesting a potential biomarker role, but the authors recommend further research for validation due to the new insights.
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Introduction: Rectal cancer is one of the most common malignancies in developed countries. However, despite the increasingly better preoperative diagnostics, adaptation of surgical techniques to the location and advancement of the tumor, the combination of surgical treatment with neoadjuvant therapy and adjuvant treatment, standardized control tests, Poland still has not obtained satisfactory results regarding long-term survival. In addition, the effects of the therapy often differ significantly from those expected by patients and the doctors treating them.

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