Pilot study results from the assertive community treatment transitional intervention program in Switzerland.

Often, after an inpatient stay, early readmission occurs, which is detrimental to the patient. University Psychiatric Clinics Basel developed a 3-month transitional intervention program to bridge inpatient and community treatment by supporting people after their discharge from the psychiatric hospital. In line with international guidelines, this transitional intervention was delivered as assertive community treatment in the homes of people who wished to participate.

A Framework for Exception From Informed Consent in Trials Enrolling Patients With ST-Segment-Elevation Myocardial Infarction and Cardiogenic Shock.

Cardiogenic shock (CS) is critical end-organ hypoperfusion attributable to reduced cardiac output. Acute ST-segment-elevation myocardial infarction with CS (AMI-CS) has high mortality. Clinical research is challenging in such patients as they often cannot provide consent, lack available legal representatives, and require initiation of therapy.

EGFR in Placental Health and Disease: Pathways, Dysfunction, and Chemical Disruption.

Formation of the placenta during gestation is required to support fetal growth and development. Derived from the placenta, trophoblast cells express nuclear and membrane-bound receptors. Among these receptors is the epidermal growth factor receptor (EGFR) which plays a key role in placental development.

Computational Engineering of siderocalin to modulate its binding affinity to the antihypertension drug candesartan.

Lipocalin family proteins have been shown to bind a vast array of small molecules and have subsequently been adapted to selectively bind specific ligands. In this study, candesartan, an antihypertension drug, was identified to bind mouse and human siderocalin in biomolecular NMR experiments, allowing for structural insights into the candesartan-siderocalin interaction. The ligand binding site was determined through an integrative structural biology approach using in silico ligand docking guided by NMR experiments.

Pearls & Oy-sters: Isolated Acquired Amusia in a Patient With Right Temporal Stroke.

Strokes in the right temporal lobe are known to cause acquired amusia, or deficits in music processing, which can be formally assessed using the online version of the Montreal Battery of Evaluation of Amusia (MBEA). Patients with acquired amusia most often present with not only amusia but also other neurologic symptoms, such as aphasia, neglect, or memory issues. We report a case of a 39-year-old man who initially presented for follow-up after a single seizure episode.