Publications by authors named "J Kjeldsen"
Safety and efficacy of faecal microbiota transplantation in patients with acute uncomplicated diverticulitis: study protocol for a randomised placebo-controlled trial.
Therap Adv Gastroenterol
January 2025
Background: Little is known about the involvement of gut microbiota in the disease course of diverticulitis and the potential benefits of manipulating the gut milieu. We propose to conduct a randomised placebo-controlled feasibility trial of faecal microbiota transplantation (FMT) given as capsules to patients with acute uncomplicated diverticulitis.
Objectives: The objective is primarily to investigate the feasibility of clinical safety, explore efficacy associated with FMT in this patient population, and examine changes in patient-reported quality of life and the composition and function of the gut microbiota.
Although interleukin (IL)-6 is considered immunosuppressive and tumor-promoting, emerging evidence suggests that it may support antitumor immunity. While combining immune checkpoint inhibitors (ICIs) and radiotherapy in patients with pancreatic cancer (PC) has yielded promising clinical results, the addition of an anti-IL-6 receptor (IL-6R) antibody has failed to elicit clinical benefits. Notably, a robust TGFβ-specific immune response at baseline in PC patients treated solely with ICIs and radiotherapy correlated with improved survival.
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- - The prevalence of obesity is rising globally, particularly among individuals with inflammatory bowel disease (IBD), leading researchers to investigate glucagon-like peptide 1 receptor agonists (GLP-1RAs) as potential anti-obesity treatments due to their weight loss benefits.
- - A nationwide Danish cohort study was conducted to assess the risk of severe side effects, specifically ileus and intestinal obstruction, in IBD patients using GLP-1RAs, utilizing health registries and adjusting for multiple factors like age, sex, and prior health issues.
- - The results of the study indicated that the use of GLP-1RAs does not increase the likelihood of ileus or intestinal obstruction in patients with IBD, suggesting
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- The incidence of inflammatory bowel disease (IBD) in the Faroe Islands has significantly increased over the last 60 years, raising concerns about environmental factors and genetic susceptibilities.
- This study compared environmental factors between Faroese IBD patients and a Danish cohort, analyzing data from 2010 to 2022.
- Findings revealed that Faroese patients had higher rates of specific vaccinations and childhood infections, different dietary habits, and variations in smoking behaviors compared to Danish patients.
: The influence of comorbidity on long-term hospitalization and mortality after COVID-19 in adults (40-59 years) and older adults (≥60 years) is yet to be explored. : This is a Danish population-based cohort study of patients with a first-time positive PCR test for COVID-19 from 1 March 2020, to 28 February 2022 (N = 1,034,103). Exposed cohorts were patients with 1) a Charlson Comorbidity Index (CCI) score of 1-2 and 2) a CCI score ≥3, who were compared to patients without comorbidity (CCI of zero) within the groups of adults (67.
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