Publications by authors named "J Kitawaki"
Neonatal uterine bleeding: Risk factors and its association with endometriosis-related symptoms later in life.
Eur J Obstet Gynecol Reprod Biol
February 2024
Objective: We examined the prevalence and risk factors in association with neonatal uterine bleeding (NUB) by retrospective search of contemporary and historical medical records and investigated the possible association between the history of NUB at birth and endometriosis-related symptoms later in life who are now young women.
Study Design: This was a retrospective case-controlled cohort study and prospective evaluation of web-based questionnaire survey on symptoms related to endometriosis among young women born with and without NUB. Multiple regression analysis was performed incorporating various confounding variables that may influence the occurrence of NUB or the reporting of endometriosis symptoms later in life.
Objectives: The effects of laparoscopic surgical management in women with stage III/IV endometriosis remain controversial. The standard extent of resection for stage III/IV endometriosis with deep endometriosis to treat endometriosis-associated infertility is debatable. This study aimed to assess the postoperative pregnancy outcomes following a routine surgical intervention for stage III/IV endometriosis patients.
View Article and Find Full Text PDFIs neonatal uterine bleeding responsible for early-onset endometriosis?
Reprod Biol Endocrinol
June 2023
Article Synopsis
- This study investigates the connection between neonatal uterine blood (NUB) and the development of early-onset endometriosis, hypothesizing that endometrial mesenchymal stem cells (eMSCs) could play a role.
- Researchers analyzed neonatal endometria and NUB samples to assess various biological markers, focusing on hormone receptors, cell proliferation, and immune cell presence.
- The results showed differences in immunoexpression between neonatal and adult endometria, but no evidence of eMSCs in NUB, challenging the proposed link between NUB and early-onset endometriosis.
Problem: Endometriosis is a proliferative disease characterized by cytokine-induced inflammation. The objective of this study was to assess cell growth and PGE production induced by TNF-α in endometriotic stromal cells (ESCs) in spheroid cell culture and to identify the signaling pathway involved with a view to finding new therapeutic targets for endometriosis.
Method Of Study: Tissue samples were collected from patients with and without endometriosis.