Individual Radiosensitivity as a Risk Factor for the Radiation-Induced Acute Radiodermatitis.

Background: Up to 95% of irradiated patients suffer from ionizing radiation (IR) induced early skin reaction, acute radiation dermatitis (ARD). Some experts think that additional skin hydration can reduce acute skin reactions. Individual radiosensitivity (IRS) determined from lymphocytes may help to predict acute radiation toxicity.

Acute Radiation Dermatitis Evaluation with Reflectance Confocal Microscopy: A Prospective Study.

Background: During radiotherapy (RT), most breast cancer patients experience ionizing radiation (IR)-induced skin injury-acute radiation dermatitis (ARD). The severity of ARD is determined by a physician according to CTCAE or RTOG scales, which are subjective. Reflectance confocal microscopy (RCM) is a noninvasive skin imaging technique offering cellular resolution.

APPLICATION OF REFLECTANCE CONFOCAL MICROSCOPY FOR EARLY DIAGNOSIS OF RADIATION-INDUCED ACUTE DERMATITIS IN RADIOSENSITIVE PATIENT: CASE STUDY.

According to the guidelines on cancer treatment up to 52% of newly diagnosed cancer patients should be treated with external beam radiotherapy. Ionizing radiation (IR)-induced skin injury (radiation dermatitis) occurs in up to 95% of radiotherapy patients and can manifest from mild erythema till necrosis and ulceration. Individual radiosensitivity was proposed to be an important factor for the development of adverse reactions to IR.