Publications by authors named "J Kisiel"
Introduction: Blood-based tests represent a compelling option for early detection and management of cancers and other chronic diseases. While they may increase patient engagement, assumptions about greater adherence in clinical practice need further evaluation. This systematic review aimed to evaluate real-world adherence to established blood-based tests for commonly recommended screening indications to inform expectations for average-risk colorectal cancer (CRC) screening.
View Article and Find Full Text PDFObjectives: To describe member adherence to a mail-based, health insurer-sponsored gap closure program for colorectal cancer (CRC) screening using multi-target stool DNA (mt-sDNA; Cologuard) tests.
Methods: Combined patient data from Exact Sciences Laboratories LLC and data from mass-mailed mt-sDNA orders placed by a large Medicare Advantage Insurance Plan were analyzed (03/01/2023-06/30/2023). Adherence and time to test return were the primary and secondary outcomes, respectively.
Lymphoma is one of the leading causes of cancer and cancer deaths and yet has not been amenable to population screening. The role of methylated DNA markers (MDMs) in the detection of lymphoma has not been extensively studied. We aimed to discover, validate, and test tissue-derived MDMs of lymphoma in archival plasma specimens.
View Article and Find Full Text PDFArticle Synopsis
- A multicenter study aimed to evaluate the effectiveness of methylated DNA markers (MDMs) found in pancreatic juice (PJ) for detecting pancreatic ductal adenocarcinoma (PDAC) when used alone and in combination with a blood test, CA 19-9.
- The analysis included DNA samples from 88 confirmed PDAC cases and 134 control cases, utilizing logistic regression to summarize accuracy through the area under the receiver-operating characteristic curve (AUROC).
- Results showed that the combination model of PJ-MDMs and CA 19-9 achieved a higher accuracy (AUROC of 0.95) compared to using PJ-MDMs (0.87) or CA 19-9 alone (0
Background: Crohn's disease (CD) exhibits variability in colorectal cancer (CRC) incidence and prognostic factors due to diverse clinical and behavioral characteristics, presenting inconsistencies between Western and Eastern patients.
Objectives: This study compared clinical characteristics between CD patients with CRC from the US and Korean tertiary referral centers and defined the prognostic factors related to mortality.
Design: Retrospective study.