Publications by authors named "J Kirkwood"
Higher blood pressure targets for hypertension in older adults.
Cochrane Database Syst Rev
December 2024
Background: This is an update of the original Cochrane review, published in 2017. Eight out of 10 major antihypertensive trials in adults, 65 years of age or older, attempted to achieve a target systolic blood pressure (BP) of < 160 mmHg. Collectively, these trials demonstrated cardiovascular benefit for treatment, compared to no treatment, for older adults with BP > 160 mmHg.
View Article and Find Full Text PDFArticle Synopsis
- The increasing prevalence of gestational diabetes mellitus (GDM) has led to the development of a mobile health (mHealth) solution aimed at improving care and management through predictive modeling and risk stratification.
- "MyGDM" is a user-centered mHealth tool that includes a clinical dashboard for healthcare providers and a patient-facing app, offering educational resources, meal ideas, and options for culturally inclusive communication.
- Feedback from both healthcare professionals and women with GDM was overwhelmingly positive, with all participants in questionnaires indicating the app would fit into their lifestyles and assist in managing their condition.
Background: While the prognostic role of tertiary lymphoid structures (TLS) has been well studied in solid cancers, the prevalence and impact of immature precursor lymphoid structures known as lymphoid aggregates (LA) remain unresolved in relation to the disease process. In this study, we examined characteristics and the prognostic utility of LA and TLS status in histological samples from patients with melanoma.
Methods: We assessed The Cancer Genomic Atlas-skin cutaneous melanoma digital slides and melanoma specimens from the University of Pittsburgh for the presence of LA and TLS using H&E staining, multiplex immunofluorescence (mIF) and transcriptomic analyses.
Article Synopsis
- * Out of 31 patients, 55% showed a significant drop in tumor activity (major pathologic response), along with increased immune cell presence in the tumors.
- * Findings indicate that this combination therapy not only activates various immune responses but is also linked to specific genetic markers in immune cells and changes in gut microbiota, suggesting potential pathways for enhancing treatment outcomes.