Predicting Neurodegenerative Diseases: Unveiling the Interplay of Genetics and Social Determinants.

Background: Predicting Alzheimer's disease (AD) and frontotemporal dementia (FTD) using polygenic risk scores (PRS) for late‐onset forms holds promise, but its accuracy might be influenced by social determinants of health (SDOH). This study explores how considering SDOH alongside genes can improve prediction, focusing on potential differences for each disease.

Methods: Employing logistic regression in 677 individuals (287 AD, 102 FTD, and 288 controls) aged 40‐80 from the ReDLat study across six Latin American countries, we investigated the potential for SDOH to modify the association between PRS and susceptibility to AD and FTD.

Postoperative Supine Sleeping Position Following Total Knee Arthroplasty Decreases Knee Flexion Contractures.

Background: Total knee arthroplasty (TKA) is an orthopaedic operation that improves quality of life and reduces pain in patients with disabling arthritis of the knee. One commonly recognized postoperative complication is flexion contracture of the knee. While early physical therapy and range of motion (ROM) exercises have helped improve ROM postoperatively, flexion contractures still remain a significant postoperative complication of TKA.

Developing a Sleep Algxorithm to Support a Digital Medicine System: Noninterventional, Observational Sleep Study.

Background: Sleep-wake patterns are important behavioral biomarkers for patients with serious mental illness (SMI), providing insight into their well-being. The gold standard for monitoring sleep is polysomnography (PSG), which requires a sleep lab facility; however, advances in wearable sensor technology allow for real-world sleep-wake monitoring.

Objective: The goal of this study was to develop a PSG-validated sleep algorithm using accelerometer (ACC) and electrocardiogram (ECG) data from a wearable patch to accurately quantify sleep in a real-world setting.

Aerial Imagery Reveals Abnormal Stingray, (Myliobatiformes: Dasyatidae), in the Central Red Sea.

While morphological abnormalities have been widely reported in batomorphs, ontogenetic deformities of the posterior pectoral fin are rare. In this paper, we present a bluespotted ribbontail ray, (Forsskål, 1775), with symmetrically deformed posterior pectoral fins. The specimen was observed through aerial imagery on a coastal sandflat in the central Red Sea (22.