Publications by authors named "J Kinnunen"
Objective: To study ferritin levels, and potential factors influencing them, in women with polycystic ovary syndrome (PCOS), and to investigate potential associations between ferritin levels and other parameters in these women.
Design: Longitudinal general population -based cohort study, including data from both questionnaires and clinical measurements.
Subjects: The study was conducted with data from the participants of the Women's Health Study, including a total of 1918 Finnish women, around 35 years of age.
Article Synopsis
- The inflammatory tumor microenvironment (TME) significantly contributes to cancer progression, particularly in prostate cancer.
- Tumor-associated macrophages (especially M1, pro-inflammatory types) promote cancer stemness while suppressing androgen response in prostate cancer cells.
- The study suggests that M1 macrophages do this by releasing factors that activate the NFκB signaling pathway, leading to increased expression of cancer stem cell markers like NANOG and KLF4.
The Women's Health Study (WENDY) was conducted to improve insights into women's health and health burden. It provides a unique, comprehensive data source that can be broadly utilised to understand gynaecological symptoms, diseases, and their relation to metabolic and overall health more deeply in a population-based setting. The study was conducted in Finland from May 2020 to October 2022.
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- The study investigates how time-in-therapeutic-range (TTR) impacts the effectiveness and safety of warfarin compared to direct oral anticoagulants (DOACs) in patients with atrial fibrillation (AF).
- Researchers analyzed data from a nationwide Finnish study between 2011 and 2018, using hazard ratios to assess risks of ischaemic stroke, intracranial hemorrhage, and mortality among patients using warfarin and different DOACs.
- Results indicated that lower TTR was associated with higher risks of complications and mortality in warfarin users, while differences in outcomes between high TTR groups and standard dose DOACs were minimal.