Publications by authors named "J Kilpatrick"
Article Synopsis
- Eribulin is a microtubule dynamics inhibitor that shows potential for managing brain tumors, especially breast cancer brain metastases, due to its lower protein binding and resistance to P-glycoprotein extrusion.
- A clinical study involved administering eribulin to cancer patients post-tumor removal, with samples analyzed to measure its concentrations in the brain and plasma.
- Results indicated higher concentrations of eribulin in areas where the blood-brain barrier was disrupted, but overall levels in the brain were not enough to confirm consistent clinical effectiveness against brain tumors.
Chimeric antigen receptor T cell (CAR-T) therapy is an emerging strategy to improve treatment outcomes for recurrent high-grade glioma, a cancer that responds poorly to current therapies. Here we report a completed phase I trial evaluating IL-13Rα2-targeted CAR-T cells in 65 patients with recurrent high-grade glioma, the majority being recurrent glioblastoma (rGBM). Primary objectives were safety and feasibility, maximum tolerated dose/maximum feasible dose and a recommended phase 2 dose plan.
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- Pediatric brain tumor prognosis is currently poor, but there is hope that CAR T cell therapy could improve outcomes, as indicated by a study involving the first six treated patients in a clinical trial (NCT04510051).
- Interim results show that three out of five evaluable patients experienced some temporary clinical benefits, while overall there were no serious side effects from the treatment, despite some patients experiencing common issues like cytopenias.
- Analysis of immune responses revealed interesting interactions between CAR T cells and the patient's immune system, highlighting differences in T cell populations in the cerebrospinal fluid compared to peripheral blood, suggesting the need for careful sampling in future studies.
Introduction: Uncertainty is an inherent part of medicine. Prior work has trained medical students to better communicate diagnostic uncertainty; however, this work touches on only one aspect of the uncertainty students will face in practice. We developed a session to provide them with a taxonomy for categorizing the various types of uncertainty, as well as a framework to apply when navigating uncertainty during clinical challenges.
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