Publications by authors named "J Kikhney"
Objectives: The study aimed to analyze outcomes of surgery for blood culture-negative infective endocarditis (BCNIE) and to evaluate the role of molecular biological imaging.
Methods: Patients undergoing surgery for native or prosthetic valve endocarditis from 2013 to 2022 were analyzed regarding blood culture-positive infective endocarditis (BCPIE) and BCNIE. For laboratory diagnostics in BCNIE, excised valves or prostheses underwent conventional microbiological culture and fluorescence in situ hybridization combined with 16S rRNA-gene polymerase chain reaction and sequencing (FISHseq).
Background: Mycobacterium chelonae is a rare cause of infective endocarditis that is difficult to diagnose and treat. After we found M chelonae in a series of patients, we aimed to investigate its role in cardiovascular prosthesis dysfunction and contamination of bioprostheses as a possible cause of infection.
Methods: In this collaborative microbiological study, we report on nine patients treated in three cardiovascular surgical departments in Germany, who were found to have M chelonae infection after receiving BioIntegral bioprostheses.
Article Synopsis
- Endoscopic lung volume reduction (ELVR) with endobronchial valves (EBV) is a treatment for severe COPD patients suffering from emphysema and hyperinflation, but it may lead to complications like infections.
- A study of ten COPD patients who had EBV removed revealed the presence of bacterial infections and biofilms on the valves, which could contribute to worsening symptoms and increased exacerbations.
- The findings highlight the need for further research to understand the role of these infections and develop treatments to prevent them in patients undergoing ELVR.
(1) Background: The successful treatment of infective endocarditis (IE) relies on detecting causative pathogens to administer targeted antibiotic therapy. In addition to standard microbiological cultivation of pathogens from tissue obtained during heart valve surgery, the potential of molecular biological methods was evaluated. (2) Methods: A retrospective study was performed on heart valve tissue from 207 patients who underwent heart valve surgery for IE.
View Article and Find Full Text PDFUnlabelled: Implant-associated infections are a devastating complication in surgery. Especially in infections with biofilm-forming microorganisms, the identification of the causing microorganism remains a challenge. However, the classification as biofilm is not possible with conventional polymerase chain reaction or culture-based diagnostics.
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