Publications by authors named "J Kiiski"
Background: Paracetamol-codeine combination tablet is widely used in pain management after day surgery. For safety reasons, its use has decreased in recent years. Codeine is a prodrug metabolised in the liver by the cytochrome P450 2D6 (CYP2D6) enzyme to morphine that produces the analgesic effect of codeine.
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- Researchers studied how different genetic variations in the CYP2D6 enzyme affect the body's ability to metabolize codeine into morphine, which is vital for determining pain relief and potential side effects.
- A clinical trial involving 1000 patients was conducted, where their CYP2D6 genotypes were analyzed after they were given a standard dose of codeine, and the relationship between their genetic makeup and morphine exposure was modeled.
- The results showed that individuals with certain genetic variations (like CYP2D6*10 and *41) had less effective metabolism of codeine, leading to significantly higher or lower morphine levels in the bloodstream, highlighting the importance of genetic testing for safer opioid prescribing.
Background: Vascularized lymph node transfer (VLNT) is one option among other surgical treatments in the management of breast cancer-related lymphedema (BCRL). The cause of concern regarding VLNT harvested from the groin has been the potential development of secondary lower-extremity lymphedema. This study explored the risks associated with donor-site morbidity following groin VLNT, with or without concomitant breast reconstruction.
View Article and Find Full Text PDFBackground: Breast cancer-related lymphedema (BCRL) is a common complication lacking medical treatment. Lymfactin® is an adenovirus type 5-based gene therapy and prolymphangiogenic growth factor vector that induces vascular endothelial growth factor C (VEGF-C) expression. Our aim was to evaluate the therapeutic effect of Lymfactin® with vascularized lymph node transfer (VLNT).
View Article and Find Full Text PDFWhole-body vibration training (WBV) training has shown positive effects on bone strength, muscle strength, and balance, but the evidence on fall prevention is not yet persuasive. This study aimed to evaluate the effectiveness of WBV training in preventing falls and improving physical performance among older adults at fall risk. The study was an assessor- and participant-blinded, randomized, and controlled 10-week training trial with a 10-month follow-up.
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