Publications by authors named "J Khiaowichit"

Alteration of mucin-type O-glycosylation is implicated in tumor progression and metastasis of cholangiocarcinoma (CCA). Core 1 β1-3 Galactosyltransferase (C1GALT1) is a primary enzyme that regulates the elongation of core 1-derived mucin-type O-glycans. Dysregulation of C1GALT1 has been documented in multiple cancers and is associated with aberrant core 1 O-glycosylation and cancer aggressiveness; however, the expression of C1GALT1 and its role in CCA progression remains unknown.

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Article Synopsis
  • RNF43 is a ubiquitin E3 ligase that negatively impacts Wnt/β-catenin signaling, and its loss or mutation in cholangiocarcinoma (CCA) correlates with worse patient outcomes.
  • Overexpressing RNF43 in a CCA cell line led to the inhibition of Wnt/β-catenin signaling, resulting in reduced cell proliferation and migration, alongside increased sensitivity to the chemotherapy drug 5-fluorouracil.
  • These findings suggest that RNF43 may act as a tumor suppressor in CCA by blocking key molecular pathways involved in cancer progression.
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Objective: This study aimed to investigate the expression of -linked glycoprotein glycans in tissue of patients with cholangiocarcinoma compared with adjacent normal tissue.

Methods: Sixty patients with cholangiocarcinoma were included in the study. Permethylated -linked glycans from intrahepatic cholangiocarcinoma tissue and adjacent normal tissue were analyzed using nano-spray ionization-linear ion trap mass spectrometry.

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Objective: To investigate the expression of glycosphingolipids in serum and tissue from patients with cholangiocarcinoma compared with healthy controls.

Methods: Nanospray ionization-linear ion trap mass spectrometry (NSI-MS) was used to demonstrate the comparative structural glycomics of glycosphingolipids in serum from patients with cholangiocarcinoma (n=15), compared with healthy controls (n = 15). GM2 expression in cholangiocarcinoma tissues (n = 60) was evaluated by immunohistochemistry.

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This study aimed to determine the prevalence and intensity of intestinal helminth infections (IHIs) among rural villagers in Waeng Noi district, Khon Kaen Province, northeastern Thailand. A cross-sectional study was conducted between March 1 and July 30, 2018, among rural villagers from 30 rural villages in 2 subdistricts. The participants were selected from the village enrollment list after proportional allocation of the total sample size.

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