A defect in the fusion of Müllerian ducts results in the uterine malformation of the bicornuate uterus. The bicornuate uterus is an uncommon condition, and it is associated with adverse early pregnancy and antenatal events, such as recurrent miscarriages, preterm labor, and delivery. The bicornuate uterus has two symmetric uterine cavities that are fused caudally and have some degree of communication between the two cavities, usually at the uterine isthmus.
View Article and Find Full Text PDFBackground: Cervical cancer's lymphatic spread primarily begins from the sentinel lymph nodes (SLNs), underlining their pivotal role in disease metastasis. However, these nodes' immune gene expression profiles and immunoregulation mechanisms have yet to be explored.
Methods: Our study aimed to elucidate the immune cell populations and their roles in the immune gene expression profile of negative SLNs compared with positive SLNs and non-SLNs using Nanostring RNA seq analysis.