Publications by authors named "J Kemppainen"
The traditional understanding of brain function has predominantly focused on chemical and electrical processes. However, new research in fruit fly (Drosophila) binocular vision reveals ultrafast photomechanical photoreceptor movements significantly enhance information processing, thereby impacting a fly's perception of its environment and behaviour. The coding advantages resulting from these mechanical processes suggest that similar physical motion-based coding strategies may affect neural communication ubiquitously.
View Article and Find Full Text PDFObjective: To execute a large-scale, decentralized, clinical-grade whole exome sequencing study, coined Tapestry, for clinical practice, research discovery, and genomic education.
Patients And Methods: Between July 1, 2020, and May 31, 2024, we invited 1,287,608 adult Mayo Clinic patients to participate in Tapestry. Of those contacted, 114,673 patients were consented and 98,222 (65.
Article Synopsis
- - The study explores the potential relationship between chemokines and tumor-infiltrating lymphocytes (TILs) in the prognosis of seminoma, a type of testicular cancer, highlighting the need for more research in this area.
- - Researchers analyzed samples from 25 seminoma patients and 24 controls, finding that chemokine profiles were significantly different in seminoma compared to normal testis, with notable over-expression in TILs.
- - Results suggest that the expression of chemokines and the proliferation marker Ki-67 in TILs could be valuable indicators for predicting relapse and understanding seminoma biology, calling for further studies.
Article Synopsis
- The study assesses how well AI chatbots GPT-4o and Claude-3 perform in handling medical questions with diagnostic uncertainty, compared to Family Medicine residents.
- Researchers used questions from Progress Tests taken by Family Medicine residents, focusing on scenarios lacking clear diagnoses that require complex reasoning to solve.
- Results showed that both chatbots scored lower than the residents on these challenging questions, with GPT-4o scoring 53.3% and Claude-3 scoring 57.7%, while the residents scored around 61-63%.
The simulation of chemical reactions and mechanical properties including failure from atoms to the micrometer scale remains a longstanding challenge in chemistry and materials science. Bottlenecks include computational feasibility, reliability, and cost. We introduce a method for reactive molecular dynamics simulations using a clean replacement of non-reactive classical harmonic bond potentials with reactive, energy-conserving Morse potentials, called the Reactive INTERFACE Force Field (IFF-R).
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