Publications by authors named "J Keith Bertrand"
Transient receptor potential channel 1 (TRPC1) is a widely expressed mechanosensitive ion channel located within the endoplasmic reticulum membrane, crucial for refilling depleted internal calcium stores during activation of calcium-dependent signaling pathways. Here, we demonstrate that TRPC1 activity is protective within cartilage homeostasis in the prevention of cellular senescence associated cartilage breakdown during mechanical and inflammatory challenge. We reveal that TRPC1 loss is associated with early stages of osteoarthritis (OA) and plays a non-redundant role in calcium signaling in chondrocytes.
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- * Data from 203 patients from phase I/II clinical trials were used, creating both longitudinal and PFS-specific models that were then integrated into a joint model to capture their interactions.
- * The final model indicated that serum M-protein changes correlate with PFS and validated the dosing regimen of Isa in a pivotal phase III study, supporting ongoing research and treatment approaches in multiple myeloma. *
Objectives: The American Academy of Pediatrics recommends clinicians who treat pediatric patients screen for prenatal alcohol exposure (PAE) to facilitate the identification of children with fetal alcohol spectrum disorders and promote timely access to behavioral and cognitive interventions. We evaluated how frequently clinicians inquire about PAE in their pediatric patient interactions and the methods used to ascertain this information.
Methods: We analyzed data from the Fall 2020 DocStyles survey, a web-based survey of primary healthcare professionals (n = 1754).
Article Synopsis
- The study focuses on how Ophrys orchids have developed diverse floral traits (scent, color, shape) as they undergo early stages of speciation in isolated populations.
- A new method was used to analyze floral traits and their genetic basis, revealing significant genetic divergence linked to these phenotypic variations, particularly in floral odor.
- The research highlights the importance of understanding early speciation processes and genomic regions that may drive these adaptations, suggesting a complex interplay of selection pressures on different floral characteristics.