Publications by authors named "J Kehrmann"
Article Synopsis
- Next-generation sequencing for microbial communities is now common, but it requires significant computational resources, highlighting the need for automated, reproducible analysis pipelines.
- RiboSnake is a new QIIME2-based pipeline built with Snakemake that simplifies gene amplicon sequencing data analysis, offering pre-optimized settings for various sample types.
- By providing a customizable and user-friendly tool for microbiome analyses, RiboSnake improves efficiency and accessibility for researchers and is available for use on GitHub.
Article Synopsis
- Mycosis fungoides (MF) is a common type of skin cancer that makes it hard to tell harmful T cells from normal ones.
- Researchers used single-cell RNA and T-cell receptor sequencing on skin samples from 12 MF patients, analyzing 18,630 T cells from 9 of them to distinguish between malignant and reactive cells.
- The study found unique gene signatures in malignant T cells that could help differentiate them from reactive T cells, revealing significant variations in cell characteristics among patients.
Unlabelled: This study evaluates the growth of mycobacteria in samples from cystic fibrosis (CF) patients and tissue samples using the mycobacteria growth indicator tube (MGIT) incubated at 30°C in comparison to conventional MGIT cultures incubated at 37°C in a BACTEC MGIT 960 device and solid media incubated at 36°C and 30°C. A total of 1,549 samples were analyzed, of which 202 mycobacterial isolates were cultured from 197 positive specimens, including five mixed cultures. The highest detection rate was achieved from MGIT at 30°C, with 84.
View Article and Find Full Text PDFArticle Synopsis
- The Mycobacterium avium complex (MAC) includes 12 species but focuses on M. avium, M. intracellulare subsp. intracellulare, and M. intracellulare subsp. chimaera, which are significant for clinical relevance in Central Europe.
- Whole genome sequencing was performed on 610 MAC isolates from different countries, allowing for phylogenetic analysis and identification of resistance and virulence genes.
- Results showed clustering of isolates with minimal SNP differences, but no clear correlation between genetic data and clinical outcomes, with specific species being less common in cases of extra-pulmonary disease.
Hypercalcemia as a rare manifestation of immune reconstitution inflammatory syndrome (IRIS) in a person living with Human Immunodeficiency Virus (HIV) with disseminated nontuberculous mycobacteriosis.
Maximilian Webendoerfer Margarethe Konik Markus Zettler Johannes Wienker Josefine Rawitzer Jan Kehrmann
Infection
August 2024
Article Synopsis
- A case was reported of a 39-year-old male living with HIV who developed hypercalcemia and acute kidney damage due to immune reconstitution inflammatory syndrome (IRIS) and disseminated Mycobacterium avium infection.
- The patient experienced significant weight loss, muscle weakness, and had laboratory findings confirming high serum calcium levels and kidney damage despite being on antiretroviral therapy and other medications.
- Treatment involving diuretics, bisphosphonates, and calcitonin successfully normalized calcium levels and improved kidney function, highlighting the rare but critical nature of hypercalcemia linked to IRIS in HIV patients.