J Turk Ger Gynecol Assoc
December 2024
Functional enhancer annotation is critical for understanding tissue-specific transcriptional regulation and prioritizing disease-associated non-coding variants. However, unbiased enhancer discovery in disease-relevant contexts remains challenging. To identify enhancers pertinent to diabetes, we conducted a CRISPR interference (CRISPRi) screen in the human pluripotent stem cell (hPSC) pancreatic differentiation system.
View Article and Find Full Text PDFFunctional enhancer annotation is a valuable first step for understanding tissue-specific transcriptional regulation and prioritizing disease-associated non-coding variants for investigation. However, unbiased enhancer discovery in physiologically relevant contexts remains a major challenge. To discover regulatory elements pertinent to diabetes, we conducted a CRISPR interference screen in the human pluripotent stem cell (hPSC) pancreatic differentiation system.
View Article and Find Full Text PDFComplex band structure (CBS) emerges when translational symmetry is broken and material states with complex wavevectors become admissible. The resulting complex bands continuously connect conventional bands and their shapes are directly related to measurable physical quantities. To date, interpretations of complex bands usually assume they are semielliptical because this is the shape produced by the Su-Schrieffer-Heeger (SSH) model.
View Article and Find Full Text PDFBackground And Objective: Rigid tracheobronchoscopy (RTB) has seen an increasing interest over the last decades with the development of the field of IPM but no benchmark exists for complication rates in RTB. We aimed to establish benchmarks for complication rates in RTB.
Methods: A multicentric retrospective analysis of RTB performed between 2009 and 2015 in eight participating centres was performed.