Publications by authors named "J Kaunitz"
The Janus kinase/signal transducer and activator of transfection (JAK/STAT) system is comprised of multiple cell surface receptors, receptor tyrosine kinases, and signal transducers that are key components of numerous systems involved in malignancy, inflammation, immune surveillance and development, cellular proliferation, metabolism, differentiation, apoptosis, and hematologic disorders, all of which when disrupted can produce severe disease. Nevertheless, small molecule inhibitors of the four known JAKs, termed JAKinibs, have found therapeutic indications for a broad category of diseases. In this perspective, I will summarize the development of JAK inhibitors, whose origins were in antiquity, with particular attention to their use in treating patients with inflammatory bowel disease (IBD).
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- The study investigates how a common fungus in the human gut microbiome interacts with the host's immune response, specifically focusing on tissue expression in germ-free mice colonized with the fungus.
- It finds that certain genes related to NADPH oxidase activity are activated during the fungus's transition from yeast to hyphal form, which is influenced by a toxin called candidalysin and the IL-17 receptor.
- The loss of a specific enzyme (DUOX2) results in reduced fungal colonization and changes in fungal structure, highlighting a complex relationship between the fungus, host immune responses, and the role of IL-17A in regulating gut colonization.
Background/aims: We examined the involvement of cholecystokinin (CCK) in the exacerbation of indomethacin (IND)-induced gastric antral ulcers by gastroparesis caused by atropine or dopamine in mice.
Methods: Male mice were fed for 2 h (re-feeding) following a 22-h fast. Indomethacin (IND; 10 mg/kg, s.
Background/aims: We examined the contributions of gastric emptying and duodenogastric bile reflux in the formation of gastric antral ulcers induced by NSAIDs in mice.
Methods: We used the murine re-fed indomethacin (IND) experimental ulcer model. Outcome measures included the appearance of gastric lesions 24 h after IND treatment and the assessment of gastric contents and the concentration of bile acids 1.