Publications by authors named "J Karisa"
Article Synopsis
- Lymphatic filariasis (LF) is a neglected tropical disease caused by mosquito-borne parasites affecting 51 million people globally, with mass drug administration recommended by WHO in endemic areas like coastal Kenya.
- In 2022, a study collected over 18,000 mosquitoes from LF-endemic counties in Kenya to analyze infection rates of Wuchereria bancrofti, utilizing molecular xenomonitoring methods.
- Results indicated higher infection rates in Kilifi County at 35.4% compared to 5.3% in Taita Taveta, with major vectors identified including An. rivulorum, An. funestus, and An. arabiensis, highlighting the need for targeted interventions.
Article Synopsis
- The study aimed to assess how different dosing regimens of ivermectin affect the survival of malaria vectors (mosquitoes) and their potential to reduce malaria transmission.
- An open-label randomized control trial was conducted in Kenya with 36 participants, comparing a single dose of ivermectin, a 3-day regimen of ivermectin, albendazole, and a control group with no treatment.
- Results indicated that both ivermectin regimens significantly impacted mosquito survival within the first week, but the single dose proved to be more effective over a 10-day period compared to the multi-day regimen.
Background: Protein analysis using matrix-assisted laser desorption/ionisation time-of-flight mass-spectrometry (MALDI-TOF MS) represents a promising tool for entomological surveillance. In this study we tested the discriminative power of this tool for measuring species and blood meal source of main Afrotropical malaria vectors on the Kenyan coast.
Methods: Mosquito collections were conducted along the coastal region of Kenya.
Background: Ivermectin (IVM) mass drug administration is a candidate complementary malaria vector control tool. Ingestion of blood from IVM treated hosts results in reduced survival in mosquitoes. Estimating bio-efficacy of IVM on wild-caught mosquitoes requires they ingest the drug in a blood meal either through a membrane or direct feeding on a treated host.
View Article and Find Full Text PDFBackground: Malaria remains one of the most important infectious diseases in sub-Saharan Africa, responsible for approximately 228 million cases and 602,000 deaths in 2020. In this region, malaria transmission is driven mainly by mosquitoes of the Anopheles gambiae and, more recently, Anopheles funestus complex. The gains made in malaria control are threatened by insecticide resistance and behavioural plasticity among these vectors.
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