The adenine nucleotide translocase family underlies cardiac ischemia-reperfusion injury through the mitochondrial permeability pore independently of cyclophilin D.

The mitochondrial permeability transition pore (mPTP) is implicated in cardiac ischemia-reperfusion (I/R) injury. During I/R, elevated mitochondrial Ca triggers mPTP opening, leading to necrotic cell death. Although nonessential regulators of this pore are characterized, the molecular identity of the pore-forming component remains elusive.

PKC-mediated phosphorylation governs the stability and function of CELF1 as a driver of EMT in breast epithelial cells.

Epithelial to mesenchymal transition (EMT) is believed to be a principal factor contributing to cancer metastasis. The post-transcriptional and post-translational mechanisms underlying EMT are comparatively underexplored. We previously demonstrated that the CELF1 RNA binding protein is necessary and sufficient to drive the EMT of breast epithelial cells, and that the relative protein expression of CELF1 in this context was dictated at the post-translational level.

Beyond Pearson's Correlation: Modern Nonparametric Independence Tests for Psychological Research.

When examining whether two continuous variables are associated, tests based on Pearson's, Kendall's, and Spearman's correlation coefficients are typically used. This paper explores modern nonparametric independence tests as an alternative, which, unlike traditional tests, have the ability to potentially detect any type of relationship. In addition to existing modern nonparametric independence tests, we developed and considered two novel variants of existing tests, most notably the Heller-Heller-Gorfine-Pearson (HHG-Pearson) test.

Dual nationality, anti-citizenship, and xeno-racism: Online tropes on migrant (in)gratitude, and (in)adequate Britishness of Nazanin Zaghari-Ratcliffe.

Nazanin Zaghari-Ratcliffe, an Iranian-British dual citizen, was detained by the Iranian state from April 2016 to March 2022 and charged with spying and propaganda activities against the Iranian state without due process. After her release and return to the UK, Zaghari-Ratcliffe criticized the UK government in a press conference, which triggered a Twitter campaign using the hashtags "sendherback" and "ungrateful." This campaign claimed that she did not show "enough gratitude" to Britain, the country that "saved" her.

Targeting calpain-2-mediated junctophilin-2 cleavage delays heart failure progression following myocardial infarction.

Coronary heart disease (CHD) is a prevalent cardiac disease that causes over 370,000 deaths annually in the USA. In CHD, occlusion of a coronary artery causes ischemia of the cardiac muscle, which results in myocardial infarction (MI). Junctophilin-2 (JPH2) is a membrane protein that ensures efficient calcium handling and proper excitation-contraction coupling.