Publications by authors named "J Karbwang"
Article Synopsis
- A recent phase 2A study showed that Atractylodes lancea (AL) significantly reduces tumor progression and mortality in patients with advanced-stage intrahepatic cholangiocarcinoma (iCCA) when administered in doses between 1,000 to 2,000 mg.
- The study developed a population pharmacokinetic (pop-PK) model to simulate and evaluate different dosage regimens, ultimately recommending a once-daily dose of 2,500 mg for further phase 2B studies.
- The findings suggest that this pop-PK model can effectively predict dosages and improve clinical study outcomes, potentially minimizing drug development failures.
Article Synopsis
- The study assessed how Research Ethics Committees (RECs) in seven Asian countries responded to the challenges posed by COVID-19 under tight timelines and public pressure.
- A survey involving 688 REC members and 197 chairs/secretaries revealed that while most RECs had standard operating procedures, many lacked experience in reviewing COVID-19 related protocols, with 93% of members needing additional training.
- SR-RECs demonstrated better adherence to ethical guidelines and faced more specific challenges in risk assessment and informed consent compared to NSR-RECs, highlighting the importance of established ethical review processes during health crises.*
Background And Aims: Intrahepatic cholangiocarcinoma (iCCA) is a fatal biliary tract cancer with a dismal prognosis due to ineffective diagnostic tools with limited clinical utility. This study investigated peripheral blood indices and cytokine levels to diagnose iCCA.
Methods: Blood samples were collected from healthy subjects ( = 48) and patients with advanced-stage iCCA ( = 47) during a phase I and then phase II trial, respectively.
Background: A statistical model is essential in determining the appropriate predictive indicators for therapies in many types of cancers. Predictors have been compared favorably to the traditional systems for many cancers. Thus, this study has been proposed as a new standard approach.
View Article and Find Full Text PDFBackground: Cholangiocarcinoma (CCA), the adenocarcinoma of the biliary duct, is commonly reported in Asia, with the highest incidence in northeastern Thailand. Chemotherapy of CCA has been limited by the lack of effective chemotherapeutic drugs. A series of previous in vitro and in vivo studies support further research and development of Atractylodes lancea (Thunb.
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