Publications by authors named "J Karasek"
The MBT Pathfinder is an automated colony-picking robot designed for efficient sample preparation in matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. This article presents results from three key experiments evaluating the instrument's performance in conjunction with MALDI Biotyper instrument. The method comparison experiment assessed its clinical performance, demonstrating comparable results with gram-positive, gram-negative, and anaerobic bacteria (scores larger than 2.
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- The study evaluated the 1-year outcomes of the ECMO-CS trial, which compared immediate ECMO initiation to an early conservative approach in patients with severe cardiogenic shock.
- Results showed no significant difference in all-cause mortality or other critical outcomes between the two strategies after one year.
- However, there was a suggestion that immediate ECMO could be more beneficial for patients with significantly low mean arterial pressure at baseline, indicating a possible targeted use for this treatment strategy.
Article Synopsis
- The study aimed to analyze whether ticagrelor is more effective than clopidogrel in reducing heart damage during elective coronary procedures for patients with and without prior clopidogrel treatment.
- Out of 1,882 participants, those who were not on clopidogrel had a lower rate of heart injury compared to those who had been, but overall, ticagrelor did not show significant benefits over clopidogrel for reducing complications.
- The findings suggest that clopidogrel-naive patients generally experienced fewer complications due to a lower risk profile and simpler procedures, with no notable differences in outcomes based on previously taking clopidogrel.
Background: Agar plate analysis is vital for microbiological testing in industries like food, pharmaceuticals, and biotechnology. Manual inspection is slow, laborious, and error-prone, while existing automated systems struggle with the complexity of real-world agar plates. A shortage of diverse datasets hinders the development and evaluation of robust automated systems.
View Article and Find Full Text PDFBackground: The severity of tissue hypoxia is routinely assessed by serum lactate. We aimed to determine whether early lactate levels predict outcomes in refractory out-of-hospital cardiac arrest (OHCA) treated by conventional and extracorporeal cardiopulmonary resuscitation (ECPR).
Methods: This study is a post-hoc analysis of a randomized Prague OHCA study (NCT01511666) assessing serum lactate levels in refractory OHCA treated by ECPR (the ECPR group) or conventional resuscitation with prehospital achieved return of spontaneous circulation (the ROSC group).