Radiation Recall Dermatitis After Capecitabine in a Patient With Triple Negative Breast Cancer.

A case is descibed of radiation recall dermatitis in a patient treated with adjuvant radiation therapy followed by capecitabine for triple negative breast cancer with residual disease after neoadjuvant chemotherapy.

Measuring the Impact of Academic Cancer Network Development on Clinical Integration, Quality of Care, and Patient Satisfaction.

Purpose: Many US academic centers have acquired community practices to expand their clinical care and research footprint. The objective of this assessment was to determine whether the acquisition and integration of community oncology practices by Yale/Smilow Cancer Hospital improved outcomes in quality of care, disease team integration, clinical trial accrual, and patient satisfaction at network practice sites.

Methods: We evaluated quality of care by testing the hypothesis that core Quality Oncology Practice Initiative measures at network sites that were acquired in 2012 were significantly different after their 2016 integration into the network.

Phase I clinical and pharmacologic study of weekly cisplatin combined with weekly irinotecan in patients with advanced solid tumors.

Purpose: In vitro synergy between cisplatin and irinotecan (CPT-11) has been reported. We designed a combination schedule of these agents to maximize the potential for synergistic interaction.

Patients And Methods: To maximize the opportunity for synergy, we divided the cisplatin into four consecutive weekly treatments, followed by a 2-week rest.

Phase I clinical and pharmacokinetic study of irinotecan, fluorouracil, and leucovorin in patients with advanced solid tumors.

Purpose: To determine the maximum-tolerable dose (MTD) of fluorouracil (5FU) when given with fixed doses of leucovorin and irinotecan (CPT-11), to define the dose-limiting toxicities of this combination, and to evaluate the effect of 5FU on the pharmacokinetics of CPT-11.

Patients And Methods: CPT-11, leucovorin, and 5FU were administered in repeated 6-week cycles that consisted of weekly treatment with all three drugs for 4 consecutive weeks followed by a 2-week break. On day 1 of treatment, CPT-11 alone was given by 90-minute infusion, and pharmacokinetic sampling was performed over 24 hours.

Observer reliability as a function of circumstances of assessment.

THREE FACTORS CHARACTERISTIC OF EXPERIMENTAL SETTINGS WERE HYPOTHESIZED TO INFLATE ARTIFACTUALLY THE RELIABILITY OF OBSERVATIONAL RECORDINGS: (a) knowledge by observers of when and by whom their reliability is being assessed, (b) the absence of the experimenter or a monitor to prevent cheating, and (c) computation of reliability within- (versus between-) observer group. Three groups of four observers used a standard nine-category observational code for disruptive behavior in recording from videotapes of a classroom for 22 days. Analyses revealed considerable increases in average occurrence reliability as a function of the main effects of each of the experimental factors.