Publications by authors named "J Kammerer-Ciernioch"
Contribution of Rare and Potentially Functionally Relevant Sequence Variants in Schizophrenia Risk-Locus Xq28,distal.
Am J Med Genet B Neuropsychiatr Genet
October 2024
Article Synopsis
- Duplications of a specific region on the X chromosome known as Xq28,distal have been linked to schizophrenia (SCZ) and intellectual disability in both males and females, though the exact genes involved remain unclear.
- This study aimed to explore rare genetic variants in the Xq28,distal locus and how they might contribute to SCZ risk, using advanced sequencing methods on a large sample of patients and controls.
- Despite identifying some potentially functional variants, the analysis did not find a significant difference between patients with SCZ and controls, suggesting that more research is needed to understand the role of X-chromosomal factors in neuropsychiatric disorders.
Bipolar disorder (BD) is a complex mood disorder with a strong genetic component. Recent studies suggest that microRNAs contribute to psychiatric disorder development. In BD, specific candidate microRNAs have been implicated, in particular miR-137, miR-499a, miR-708, miR-1908 and miR-2113.
View Article and Find Full Text PDFBackground: Bipolar disorder (BD) is a common and highly heritable disorder of mood. Genome-wide association studies (GWAS) have identified several independent susceptibility loci. In order to extract more biological information from GWAS data, multi-locus approaches represent powerful tools since they utilize knowledge about biological processes to integrate functional sets of genes at strongly to moderately associated loci.
View Article and Find Full Text PDFBorderline personality disorder (BOR) is determined by environmental and genetic factors, and characterized by affective instability and impulsivity, diagnostic symptoms also observed in manic phases of bipolar disorder (BIP). Up to 20% of BIP patients show comorbidity with BOR. This report describes the first case-control genome-wide association study (GWAS) of BOR, performed in one of the largest BOR patient samples worldwide.
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