Tranq Dope: Characterization of an ED cohort treated with a novel opioid withdrawal protocol in the era of fentanyl/xylazine.

Background: Treating opioid use disorder has reached a new level of challenge. Synthetic opioids and xylazine have joined the non-medical opioid supply, multiplying the complexities of caring for individuals in emergency departments (ED). This combination, known as 'tranq dope,' is poorly described in literature.

Inhibition of microglial egress in excised ganglia by human interleukin 10: implications for its activity in invertebrates.

We studied the effects of recombinant human interleukin-10 (IL-10) on invertebrate immunocytes and microglia. The present report demonstrates that the spontaneous activation of invertebrate immunocytes can be specifically inhibited by recombinant human IL-10. Induced immunocyte activation by fMLP can also be significantly diminished by IL-10.